Wade Grindle

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

Newer antidepressants are needed for the many individuals with major depressive disorder (MDD) that do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects. Recent evidence from clinical trials shows that the NMDA antagonist ketamine is a revolutionary novel antidepressant because it acts rapidly and is...

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Old Drug, New Tricks

Old Drug, New Tricks

Ketamine, better known as the club drug “Special K,” may alleviate depression when all other treatments have failed—a finding researchers stumbled across by accident. more…

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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic...

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