Wade Grindle

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic...

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