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How does ketamine elicit a rapid antidepressant response?

How does ketamine elicit a rapid antidepressant response?

A single sub-psychotomimetic dose of ketamine, an ionotropic glutamatergic n-methyl-d-aspartate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients suffering from major depressive disorder. Depressed patients report alleviation of core symptoms within two hours of a single low-dose intravenous infusion of ketamine with effects lasting up to two weeks. The rapidity of ketamine action...

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Ketamine: The Future of Depression Treatment?

Ketamine: The Future of Depression Treatment?

Every year, 13 million to 14 million Americans have major depression. Of those who seek treatment, 30% to 40% will not get better or fully recover with standard antidepressants. more…

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Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants

Newer antidepressants are needed for the many individuals with major depressive disorder (MDD) that do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects. Recent evidence from clinical trials shows that the NMDA antagonist ketamine is a revolutionary novel antidepressant because it acts rapidly and is...

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Old Drug, New Tricks

Old Drug, New Tricks

Ketamine, better known as the club drug “Special K,” may alleviate depression when all other treatments have failed—a finding researchers stumbled across by accident. more…

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A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic...

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New Psychology Today article on Ketamine

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