New Insight Into How Ketamine Works in Depression
Ketamine exerts an initial antidepressant effect by blocking the N-methyl-D-aspartate receptor (NMDAR), and the ketamine metabolite hydroxynorketamine (HNK) may extend the duration of the effect. The findings could lead to the development of safer alternatives. more… (registration required)
How Untreated Depression Contributes to the Opioid Epidemic
It can sometimes seem strange how so much of the country got hooked on opioids within just a few years. Deaths from prescription drugs like oxycodone, hydrocodone, and methadone have more than quadrupled since 1999, according to the CDC. But pain doesn’t seem to be the only culprit: About one-third of Americans have chronic pain, but not all of...
Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications
Current therapeutic approaches to depression fail for millions of patients due to lag in clinical response and non-adherence. Here we provide new support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis of eight million reports from the FDA Adverse Effect Reporting System. The results of the examination of population scale data...
Use and Safety of Ketamine: In Plain Terms
Not surprisingly, a number of you have voiced your concern about our intention to conduct a study in which ketamine, a drug known to be abused recreationally and commonly used by veterinarians, will be trialed in children. However, the current use, safety and benefits of ketamine are much greater than you might suspect. more…
Ketamine for Treatment-Resistant Depression: Top 10 Medical Innovations 2017
In this video, see why Ketamine for Treatment-Resistant Depression was one the Cleveland Clinic’s Top 10 Medical Innovations for 2017.