Old Drug, New Tricks
Ketamine, better known as the club drug “Special K,” may alleviate depression when all other treatments have failed—a finding researchers stumbled across by accident. more…
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic...